AKRON Cream 2oz

$74.95

Highly praised by the medical community, the ingredients used in our AKRON products empower skin cells to grow naturally, lending way to improved skin elasticity, appearance, and overall health.

Your skin cells should have the power to do what they’re supposed to do. At the same time, no other psoriasis approach includes as much research and scientific evidence as AKRON. In turn, we set out to make 2022 the year where people with psoriasis and their loved ones become the winners.

Skin can and will grow naturally when given the right nutrients, hydration, and care.  Every step of the way, our AKRON products are here to fulfill your highest skin care aspirations.

Category:
Red Raspberry Seed Oil, Cranberry Seed Oil, Avocado Oil, Grape Seed Oil, Rose Hips Oil, Dexpanthanol Vitamin B5, Retinol Palmitate Vitamin A, Allantoin, Niacinamide Vitamin B3, Ceramide Complex (incl Ceramide NP, Ceramide AP, Ceramide EOP, Phytosphingosine, Cholesterol and Sodium Lauroyl Lactylate), Coenzyme Q10, Palmitoyl Tripeptide-1 , Palmitoyl Tripeptide-5, Palmitoyl Tripeptide-7 and preserved with Germaben II.

Does Not Contain: Alkanolamides, stearic acid, polyethylene glycols, alkyl phenols, ceteareths, polysorbates, steareths, Diethyhexylcyclohexanes, ethylhexyl isononanoate, butylphenyl methylpropional, alpha-isomethyl ionone & hexyl cinnamal and many others.

  • Trust is established when all of the ingredients used in a product are backed by trusted scientific research also known as Medical Evidence Studies from trusted medical libraries and archives such as the U. S. Library of Medicine, Journal of Dermatology and Clinical Research and other medical archives.
  • That’s why now, a true psoriasis lotion has been developed that does not include un-vetted and chemical compounds and instead blends skin-healthy ingredients of which are backed by over 190 medical evidence research articles. Even respected commercial brands that claim to cater to sensitive skin are packed with many ingredients that have virtually no beneficial skin properties and may actually do more harm than good for someone suffering from psoriasis and other skin issues. Unfortunately, the end result is a breakdown in trust between people with psoriasis and products that claim to help.
  • lotion doesn't mess with your immune systems, it strengthens them. So stop your skin’s panic response and give it a soothing sense of calm that reaches down to the cellular level.
Remember, you can't benefit from topicals you don't use. Order some today.  
Traditional treatments use harsh ingredients that slow down immune responses and descale buildups. Instead, each AKRON ingredient below focuses on skin cell replenishment and natural growth. These ingredients and their effects include:
  • 5 Key Lipids to heal and energize your skin
  • Coenzymes to deliver key nutrients for tissue health
  • GLA & ALA Moist Fatty Acids to moisten your skin
  • Multi-Lamella Bilayer Complex to promote healthy skin barrier functionality
  • Omega 3 to improve your skin’s hydration and regulate oil levels
  • Omega 6 to stimulate healthy skin growth
  • Phospholipid Ceramide to protect against microbes and bacteria
  • Proteins to enhance your skin’s resiliency and elastin
  • Short Chain Amino Acids to properly nourish your skin
  • Skin Cell & Lipid Bilayer Powerhouses to strengthen your skin’s structural health
  • And more
  If your FDA-approved treatment plan includes some of these ingredients, that is simply not enough. All of these scientifically-researched ingredients are key for functional, balanced, and healthy skin. LipidTAC 108 Lotion features a strategically-formulated blend of science-backed ingredients that are each proven to dramatically improve skin health.
And now the medical studies:   Our AKRON Skin Care Cream contains 5 nutrient rich oils responsible in providing the skin with moisturization, skin barrier repair, stimulation of collagen production, faster wound healing, anti-inflammatory properties and provides a level of UVA & UVB protection & repair.   Here is the basic vitamin and nutrient composition of each:  
  • Red Raspberry Seed Oil (Rich in vitamins A, C & E, alpha linolenic acid (ALA), omega-6 & 9 fatty acids & phospholipids):
  • Cranberry Seed Oil: (High in vitamins A, C, E & K, alpha linolenic acid (ALA),, N-3 & N-9 fatty acids & phospholipids):
  • Avocado Oil: (High in vitamins A, B1, B2, D & E, protein, alpha linolenic acid (ALA), omega-6 & 9 fatty acids & phospholipids):
  • Rose Hips Oil: (High in vitamins A, C & E, alpha linolenic acid (ALA), omega-6       & 9 fatty acids, Olecic acid & phospholipids):
  • Grape Seed Oil: (High in vitamin E, alpha linolenic acid (ALA), omega-3, 6 & 9 fatty acids, Olecic acid & Very high phospholipids & flavonoids):
  Now the studies on the oils and their nutrient components  
  • The vitamin A component stimulates production of collagen I, restoring the normal levels of collagen in photodamaged skin. It also increases the granular cell layers, the thickness of the epidermis, and compaction of the stratum corneum along with a reduction in the levels of melanin in the skin. Angelo, G. (2012c). Vitamin A and Skin Health. https://lpi.oregonstate.edu/mic/health-disease/skin-health/vitamin-A
  • The topical application of vitamin A also increases the extent of the subepidermal repair zone characterized by newly formed bundles of collagen. Angelo, G. (2012c). Vitamin A and Skin Health. https://lpi.oregonstate.edu/mic/health-disease/skin-health/vitamin-A
  • The vitamin C component promotes the activity of collagen hydroxylase in the fibroblasts, stabilizing the collagen cross-links. Vitamin C protects the skin against oxidative damage by scavenging the UVR-induced free radicals and reactive oxygen species. Vitamin C also reduced the production of melanin, termed melanogenesis, which facilitates the treatment of hyperpigmentation in skin conditions such as age spots and melisma. Pullar, J. M., Carr, A. C., & Vissers, M. C. M. (2017). The Roles of Vitamin C in Skin Health. Nutrients, 9(8). https://doi.org/10.3390/nu9080866
  • Vitamin C regulates the redox-sensitive signaling in the skin cells and increases the survival of the skin cells. Vitamin C reduces oxidative damage to the cellular DNA and lipids as well as modulates the release of inflammatory cytokines. Michels, A. J. (2011). Vitamin C and Skin Health. https://lpi.oregonstate.edu/mic/health-disease/skin-health/vitamin-C
  • The broad spectrum of vitamin E components including δ-tocopherol, α-tocopherol, γ-tocopherol, and tocotrienols scavenges free radicals, reduces lipid peroxidation, and inhibits photoimmunosuppression and also prevents the production of UVB-induced pyrimidine dimers. Delinasios, G. J., Karbaschi, M., Cooke, M. S., & Young, A. R. (2018). Vitamin E inhibits the UVAI induction of "light" and "dark" cyclobutane pyrimidine dimers, and oxidatively generated DNA damage, in keratinocytes. Sci Rep, 8(1), 423. https://doi.org/10.1038/s41598-017-18924-4
  • Vitamin E is an important anti-inflammatory constituent and works like this: Gamma tocotrienol and alpha tocopherol reduce the synthesis of prostaglandins and interleukins in the keratinocytes. Vitamin E also suppresses the activity of NADPH oxidase, nitric oxide synthase, and cyclooxygenase-2 (COX-2). Michels, A. J. (2012). Vitamin E and Skin Health. https://lpi.oregonstate.edu/mic/health-disease/skin-health/vitamin-E
  • The vitamin E component also prevents and reduces the gene expression of matrix metalloproteinase 1 (MMP-1) otherwise induced by exposure to IRA. Reduced synthesis of MMP-1 is associated with reduced degradation of collagen. Vitamin E contributes to improvement in skin elasticity, firmness, fine lines, wrinkles. (Farris et al., 2014; Grether-Beck et al., 2015)
  • Topical application of vitamin E accumulates in the cell membranes and extracellular lipid matrix in the stratum corneum, contributing to the antioxidant defenses of the skin. This has a sunscreen effect as it absorbs the UVR of the sun and suppresses the formation of UVR-mediated free radicals and reactive oxygen species, protecting the skin against oxidative damage. Michels, A. J. (2012). Vitamin E and Skin Health. https://lpi.oregonstate.edu/mic/health-disease/skin-health/vitamin-E
The omega-3 fatty acid component offers the skin the following:
  • Alleviates skin damage induced by Ultra Violet Radiation (UVR)
  • The fatty acids protect the skin against UV-induced damage, erythema, and inflammation.
  • The fatty acids reduce the UV-induced expression of MMP-1 or collagenase in the dermal             fibroblasts
  • The topical application of essential fatty acids also reduces the expression of MMP-9 and improves             the expression of collagen and elastic fibers accompanied by an increase in the thickness of the             epidermis. Angelo, G. (2012a). Essential Fatty Acids and Skin Health.https://lpi.oregonstate.edu/mic/health-disease/skin-health/essential-fatty-acids
  • Vitamin K improves non-transient erythema, dryness, telangiectasia, flushing, and burning of the skin in steroid-induced rosacea. Abdullah, G. A. (2020). The effectiveness of topical vitamin k cream 1% in the treatment of steroid-induced rosacea. Group, 4(38.2), 25.
  Flavonoid Components of our ingredients:  
  • Flavonoids such as hesperitin and naringenin penetrate through the skin and protect the skin against erythema caused by exposure to UVB radiation. Flavonoids tend to absorb UVR before they penetrate and damage the skin. Angelo, G. (2012b). Flavonoids and Skin Health. https://lpi.oregonstate.edu/mic/health-disease/skin-health/flavonoids
  • Flavonoids target the phase I and phase II enzymes of xenobiotic metabolism, preventing the activation of carcinogenic substances. Xenobiotic metabolism of the harmful substances in the skin prevents these substances from damaging the skin and other tissues. Angelo, G. (2012b). Flavonoids and Skin Health. https://lpi.oregonstate.edu/mic/health-disease/skin-health/flavonoids
  • Flavonoids help treat psoriasis owing to their anti-inflammatory and immunosuppressive properties. Flavonoids suppress the release of IL-4, IL-13, and histamine from mast cells and basophils, thus, exhibiting anti-allergic effects against allergic contact dermatitis. Działo, M., Mierziak, J., Korzun, U., Preisner, M., Szopa, J., & Kulma, A. (2016). The Potential of Plant Phenolics in Prevention and Therapy of Skin Disorders. Int J Mol Sci, 17(2), 160. https://doi.org/10.3390/ijms17020160
 
  • The antioxidant, anti-inflammatory, and anticancer properties of cranberry seed oil are attributed to phenolic acids, tannins, flavonoids, and anthocyanins and demonstrates radical scavenging activity which helps prevent radical-mediated damage to the DNA, proteins, and membrane lipids of the cells.. Mahdi, W. A., Alam, P., Alshetaili, A., Alshehri, S., Ghoneim, M. M., & Shakeel, F. (2022). Product Development Studies of Cranberry Seed Oil Nanoemulsion. Processes, 10(2), 393 and Ramadan, M. F. (2019). Fruit oils: Chemistry and functionality. Springer, and Yu, L. L., Zhou, K. K., & Parry, J. (2005). Antioxidant properties of cold-pressed black caraway, carrot, cranberry, and hemp seed oils. Food chemistry, 91(4), 723-729.
  • This study concludes the use of avocado oil to manage different skin conditions due to its rich combination of polyunsaturated fatty acids, this oil can be very beneficial for psoriasis and eczema patients. Flores, M., Saravia, C., Vergara, C. E., Avila, F., Valdés, H., & Ortiz-Viedma, J. (2019). Avocado Oil: Characteristics, Properties, and Applications. Molecules (Basel, Switzerland)24(11), 2172. https://doi.org/10.3390/molecules24112172
  • The fatty acids in Avocado oil help with maintaining the skin barrier to prevent water from leaking outside and also block microbes from penetrating the deeper layers of the skin. The vitamins and minerals serve as essential nutrients for the damaged skin to prevent psoriasis and eczema flare-ups.
  • This unique combination makes avocado oil ideal for dry and damaged skin like psoriasis and eczema. Rendon, A., & Schäkel, K. (2019). Psoriasis Pathogenesis and Treatment. International journal of molecular sciences20(6), 1475. https://doi.org/10.3390/ijms20061475
  • Avocade oil has cytoprotective affects. Queiroz Junior, N. F., Steffani, J. A., Machado, L., Longhi, P., Montano, M., Martins, M., Machado, S. A., Machado, A. K., & Cadoná, F. C. (2021). Antioxidant and cytoprotective effects of avocado oil and extract (Persea americana Mill) (Vero). Journal of toxicology and environmental health. Part A84(21), 875–890. https://doi.org/10.1080/15287394.2021.1945515
  • Wound healing properties of avocado oil. de Oliveira, A. P., Franco, E., Rodrigues Barreto, R., Cordeiro, D. P., de Melo, R. G., de Aquino, C. M., E Silva, A. A., de Medeiros, P. L., da Silva, T. G., Góes, A. J., & Maia, M. B. (2013). Effect of semisolid formulation of persea americana mill (avocado) oil on wound healing. Evidence-based complementary and alternative medicine : eCAM2013, 472382. https://doi.org/10.1155/2013/472382
  • The Linoleic acid component of avocado oil, in particular, is effective at rebuilding, stabilizing, and maintaining the integrity of the skin barrier. Elias, P. M., Brown, B. E., & Ziboh, V. A. (1980). The permeability barrier in essential fatty acid deficiency: evidence for a direct role for linoleic acid in barrier function. Journal of Investigative Dermatology74(4), 230-233.
  • Rosehips oil, beating the Involvement of Oxidative Stress in Psoriasis. Dobrică, E. C., Cozma, M. A., Găman, M. A., Voiculescu, V. M., & Găman, A. M. (2022). The Involvement of Oxidative Stress in Psoriasis: A Systematic Review. Antioxidants (Basel, Switzerland)11(2), 282. https://doi.org/10.3390/antiox11020282
  • Rosehips oil has bioactive compounds. Roman, I., Stănilă, A., & Stănilă, S. (2013). Bioactive compounds and antioxidant activity of Rosa canina L. biotypes from spontaneous flora of Transylvania. Chemistry Central journal7(1), 73. https://doi.org/10.1186/1752-153X-7-73
  • Rosehips oil has therapeutic applications. Mármol, I., Sánchez-de-Diego, C., Jiménez-Moreno, N., Ancín-Azpilicueta, C., & Rodríguez-Yoldi, M. J. (2017). Therapeutic Applications of Rose Hips from Different Rosa Species. International journal of molecular sciences18(6), 1137. https://doi.org/10.3390/ijms18061137
  • Rosehips oil       offer cell longevity Phetcharat, L., Wongsuphasawat, K., & Winther, K. (2015). The effectiveness of a standardized rose hip powder, containing seeds and shells of Rosa canina, on cell longevity, skin wrinkles, moisture, and elasticity. Clinical interventions in aging10, 1849–1856. https://doi.org/10.2147/CIA.S90092
  • The high levels of polyphenols and anthocyanins in rosehips oil and powder helps regulate the inflammatory cascades (ie: possible helping with flare ups) Christensen, R., Bartels, E. M., Altman, R. D., Astrup, A., & Bliddal, H. (2008). Does the hip powder of Rosa canina (rosehip) reduce pain in osteoarthritis patients?–a meta-analysis of randomized controlled trials. Osteoarthritis and Cartilage16(9), 965-972.
  • Anti-Inflammatory and Skin Barrier Repair of topical creams containing mostly plant oils Lin, T. K., Zhong, L., & Santiago, J. L. (2017). Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils. International journal of molecular sciences19(1), 70. https://doi.org/10.3390/ijms19010070
  • Synergism, ingredients helping and making other ingredients more effective. Calzetta, L., & Koziol-White, C. (2021). Pharmacological interactions: Synergism, or not synergism, that is the question. Current research in pharmacology and drug discovery2, 100046. https://doi.org/10.1016/j.crphar.2021.100046
  Grape Seed Oil:  
  • Grape seed oil can lower the levels of Nitric Oxide which is a culprit of cell proliferation. Shiri J., Cicurel A.A., & Cohen, A.D. (2011). An open-label study of herbal topical medication (Psirelax) for patients with chronic plaque psoriasis. Science World Journal, 6: 13-16.
  • Grapeseed oil is abundant in polyphenols, which suppress the expression of certain genes that produce proinflammatory cytokines. Shiri J., Cicurel A.A., & Cohen, A.D. (2011). An open-label study of herbal topical medication (Psirelax) for patients with chronic plaque psoriasis. Science World Journal, 6: 13-16.
  • Grapeseed oil promotes the release of vascular endothelial growth factor (VEGF), proanthocyanidins can play a major role in healing the skin damaged by psoriasis. Morse, T. J., & Selmont, T. A. (2013). U.S. Patent No. 8,545,904. Washington, DC: U.S. Patent and Trademark Office.
  • Grape seed oil studies concludes regenerating the skin, stimulating skin growth and reducing the TEWL (trans-epidermal water loss). Conti A., Rogers, J., Verdejo, P., Harding, L.R., Rawlings.A.V.: Seasonal influences on stratum corneum ceramide 1 fatty acids and the influence of topical essential fatty acids. J Cosmet Sci,;18: 1-12 (1995) and Jimenez-Arnau A.: Effects of Linoleic Acid Supplements on Atopic dermatitis. Adv. Exp. Med.Biol.433:285-9, (1997).
    Glyceryl Stearate (Emulsifier):
  • Glyceryl stearate emollient properties are attributed to glycerol, which is a fast-penetrating emollient and forms a protective barrier over the skin. Bárány, E., Lindberg, M., & Lodén, M. (2000). Unexpected skin barrier influence from nonionic emulsifiers. Int J Pharm, 195(1-2), 189-195. https://doi.org/10.1016/s0378-5173(99)00388-9
  • Retained moisture nourishes the skin and makes it appear soft and smooth. Salvio Neto, H., & Matos, J. d. R. (2011). Compatibility and decomposition kinetics studies of prednicarbate alone and associated with glyceryl stearate. Journal of thermal analysis and calorimetry, 103(1), 393-399
    Sodium Stearoyl Lactylate (Emulsifier):  
  • Sodium stearoyl lactylate enhances the polarity of the skin. Sodium stearoyl lactylate mixes with the lipid matrix of the stratum corneum and stimulates fluidity of the lipid chains. It is retained on the skin surface while elevating the polar component of the skin. This helps organize the lipid matrix and helps the barrier function and permeability of the skin with a emphasis on moisturization and hydration of the skin. Lemery, E., et al. (2015) Surfactants Have Multi-Fold Effects on Skin Barrier Function. European Journal of Dermatology, 25, 424-435. https://doi.org/10.1684/ejd.2015.2587
  • Lactylates are effective skin elasticity enhancing agents that improve the elasticity of the outer layer of skin, the stratum corneum. Hagan, D. B. (1995). Method for enhancing human skin elasticity by applying octanoyl lactylic acid thereto. In: Google Patents.
  • Sodium stearoyl lactylate has a hydrophilic-lipophilic balance (HLB) of 10. Especially when used in soap and creams, this compound forms a barrier on the skin and prevents the superficial layers of the layers from being removed while washing with the soap thus preserving the skins natural oils and lipids and preventing the skin from drying out. Jensen, C. D., & Andersen, K. E. (2005). Allergic contact dermatitis from sodium stearoyl lactylate, an emulsifier commonly used in food products. Contact Dermatitis, 53(2), 116. https://doi.org/10.1111/j.0105-1873.2005.0650c.x
  • This lactylate compound improves and restores the texture of the skin by reducing the scaling and dryness of the skin. Hagan, D. B. (1995). Method for enhancing human skin elasticity by applying octanoyl lactylic acid thereto. In: Google Patents.
  Cetearyl Alcohol (Emulsifier)  
  • Cetearyl Alcohol is a long chain aliphatic alcohol that functions as a viscosity agent, emollients, and emulsion stabilizer for creams and lotions among many other products. Elder, R. (1988). Final report on the safety assessment of cetearyl alcohol, cetyl alcohol, isostearyl alcohol, myristyl alcohol, and behenyl alcohol. J Am Coll Toxicol, 7(3), 359-413.
  • Cetearyl alcohol forms a protective barrier over the skin which prevents the skin from becoming dry and rough, and helps the skin become soft and smooth. Elder, R. (1988). Final report on the safety assessment of cetearyl alcohol, cetyl alcohol, isostearyl alcohol, myristyl alcohol, and behenyl alcohol. J Am Coll Toxicol, 7(3), 359-413.
  Ceramides: (Ceramide types EOS (1), NP (3), AP (6) & EOP (9))  
  • Ceramide Complex, topically applied multi-lamella system of ceramides, cholesterol and phytoshingosine (ceramide complex) play a very important role in reducing the Transepidermal Water Loss (TEWL) and subsequently increasing the hydration of skin and play a very beneficial in the improvement of the diseased skin Schmitt, T.; Lange, S.; Sonnenberger, S.; Dobner, B.; Demé, B.; Neubert, R.H.; Gooris, G.; Bouwstra, J.A. Determination of the influence of C24 D/(2R)-and L/(2S)-isomers of the CER[AP] on the lamellar structure of stratum corneum model systems using neutron diffraction. Chem. Phys. Lipids 2017, 209, 29–36.
  • Topical cream with ceramide 1 and 9 in a ratio of 0.3 percent, along with cholesterol, 1, 3 butylene glycol and aqueous lecithin were able to revitalize the damaged barrier when observed by TEM imaging. Tessema, E.N.; Gebre-Mariam, T.; Paulos, G.; Wohlrab, J.; Neubert, R.H. Delivery of oat-derived phytoceramides into the stratum corneum of the skin using nanocarriers: Formulation,
  • A of triple lipid, ceramide dominant, and barrier repair therapy is supported by two additional clinical studies and received FDA Approval Tashiro, T.; Nakaune, A.; Kosugi, T.; Arakawa, J.; Mori, H.; Serizawa, S.; Suzuki, K.; Mori, F.; Orikasa, A.; Nakamura, Y. Development of functional cosmetics “ASTALIFT JELLY AQUARYSTA”. Fugifilm Res. Dev. 2011, 56, 1–4.
  Cholesterol:  
  • Cholesterol is, or should be the most abundant individual lipid in the upper most layer of the skin, about 25 percent of the stratum corneum lipid mass is, or should be cholesterol. Lavrijsen AP, Bouwstra JA, Gooris GS, Weerheim A, Bodde HE, Ponec M. Reduced skin barrier function parallels abnormal stratum corneum lipid organization in patients with lamellar ichthyosis. J Invest Dermatol 1995; 105: 619 ± 624.
  • Cholesterol is an essential part of membrane lipid structure and plays a key role in fluidizing the membrane. It plays a pivotal role in maintaining a degree of fluidity to the epidermal waterproof barrier. This is essential for flexibility and stability of barrier which otherwise might be rigid and brittle. Wertz PW. Lipids and barrier function of the skin. Acta Dermato-Venereologica. 2000 Jan 2;80.
  • This study was conducted in which the affected patients were given topical treatment in the form of cholesterol cream, it was found that the cholesterol cream produced a positive effect on the skin and no untoward effect was observed. Lykkesfeldt G, Høyer H. Topical cholesterol treatment of recessive X-linked ichthyosis. The Lancet. 1983 Dec 10;322(8363):1337-8.
    Essential Fatty Acids:  
  • Topical administration of Essential Fatty Acids (EFA) can reduce the symptoms of deficiency in humans. Prottey C, Hartop PJ, Press M. Correction of the cutaneous manifestations of essential fatty acid deficiency in man by application of sunflower-seed oil to the skin. J Invest Dermatol. 1975;64:228-234
  • The application of omega-6 fatty acid increased the Linoleic acid (LA) content of epidermis, reduced the scale formation of skin, Transepidermal Water Loss (TEWL) was normalized after a few weeks, even the bio-chemical symptoms of Essential Fatty Acids (EFA) deficiency were corrected. Press M, Hartop PJ, Prottey C. Correction of essential fatty-acid deficiency in man by the cutaneous application of sunflower-seed oil. Lancet. 1974;1:597-598.
  • Essential Fatty Acids (EFA) correct skin deficiencies, topical application is the best route for effective treatment of skin disease. Press M, Hartop PJ, Prottey C. Correction of essential fatty-acid deficiency in man by the cutaneous application of sunflower-seed oil. Lancet. 1974;1:597-598.
  • The essential fatty acids can even protect the skin against the harmful ultraviolet radiations of the sun as suggested by these studies. Pilkington SM, Watson RE, Nicolaou A, Rhodes LE. Omega-3 polyunsaturated fatty acids: photoprotective macronutrients. Exp Dermatol. 2011;20:537-543, and Sies H, Stahl W. Nutritional protection against skin damage from sunlight. Annu Rev Nutr. 2004;24:173-200.
  • Topically applied omega 3 fatty acid greatly reduced the ultra-violet B induced erythema. Puglia C, Tropea S, Rizza L, Santagati NA, Bonina F. In vitro percutaneous absorption studies and in vivo evaluation of anti-inflammatory activity of essential fatty acids (EFA) from fish oil extracts. Int J Pharm. 2005;299:41-48. (PubMed)
  • Five separate studies show the deficiency of essential fatty acids is characterized by hyper-proliferation of skin and effect the functioning of skin, disrupts the barrier functions and increase the skins Transepidermal Water Loss (TEWL). Hansen HS, Jensen B. Essential function of linoleic acid esterified in acylglucosylceramide and acylceramide in maintaining the epidermal water permeability barrier. Biochim Biophys Acta. 1985;834:357-363 and Jeppesen PB, Hoy CE, Mortensen PB. Essential fatty acid deficiency in patients receiving home parenteral nutrition. Am J Clin Nutr. 1998;68:126-133, and       Chapkin RS, Ziboh VA, McCullough JL. Dietary influences of evening primrose and fish oil on the skin of essential fatty acid-deficient. J Nutr. 1987;117:1360-1370 and Ziboh VA, Chapkin RS. Biologic significance of polyunsaturated fatty acids in the skin. Arch Dermatol. 1987;123:1686a-1690 and Press M, Hartop PJ, Prottey C. Correction of essential fatty-acid deficiency in man by the cutaneous application of sunflower-seed oil. Lancet. 1974;1:597-598.
  Phospholipids:  
  • Phospholipids are the reason that cell membrane is semipermeable i.e. only allows certain molecules to pass through the membrane while excluding other to enter the cell. Molecules that are lipid in nature or are soluble in lipids are only allowed to pass through the membrane while water and substances soluble in water are not allowed to enter or leave the cell.  Alberts B, Johnson A, Lewis J, et al. (2002). Molecular Biology of the Cell (4th ed.). New York: Garland Science. ISBN 978-0-8153-3218-3Archived from the original on 2017-12-20.
  • Phospholipids, the key component of all cell membranes. Kimbol's Biology, 2009-01-25, https://web.archive.org/web/20090125224255/http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/CellMembranes.html
  • Phospholipids absorb the water and retain it inside the skin cells which make the skin moist and healthy and when applied topically, they can enter the deep layers of the skin. Fiume Z. Final report on the safety assessment of lecithin and hydrogenated lecithin. Int J Toxicol. 2001;20(Suppl 1):21–45 and Ghyczy M, Vacata V. Concepts for topical formulations adjusted to the structure of the skin. Chim Oggi. 1999;17:12–20.
    Coenzyme Q10:
  • Coenzyme Q10 plays an important part in metabolic actions and protects against the harmful effects of reactive oxygen species (ROS). ROS are extremely dangerous to the cell, producing oxidative damage to the lipids, proteins and DNA component of the living cell K.B. Beckman and B.N. Ames, Oxidative decay of DNA, The Journal of Biological Chemistry 272(32) (1997), 19 633–19 636 and B.S. Berlett and E.R. Stadtman, Protein oxidation in aging, disease, and oxidative stress, The Journal of Biological Chemistry 272(33) (1997), 20 313–20 316.
  • Coenzyme Q10 are synthesized and present in the mitochondria and is a component of reactions which produce ATP. ATP powers 95% of the energy in our body. Okamoto T, Matsuya T, Fukunaga Y, Kishi T, Yamagami T (1989). "Human serum ubiquinol-10 levels and relationship to serum lipids". International Journal for Vitamin and Nutrition Research. 59 (3): 288–92 and Aberg F, Appelkvist EL, Dallner G, Ernster L (June 1992). "Distribution and redox state of ubiquinones in human tissues". Archives of Biochemistry and Biophysics. 295 (2): 230–4 and Shindo Y, Witt E, Han D, Epstein W, Packer L (January 1994). "Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin". The Journal of Investigative Dermatology. 102 (1): 122–4.
  • CoQ10 when applied topically exerts a beneficial effect by reducing the damage to the mitochondrial membrane, and may act as an anti-oxidant in human cells from young as well as old individuals. Hoppe U, Bergemann J, Diembeck W, Ennen J, Gohla S, Harris I, Jacob J, Kielholz J, Mei W, Pollet D, Schachtschabel D. Coenzyme Q_ {10}, a cutaneous antioxidant and energizer. Biofactors. 1999 Jan 1;9(2‐4):371-8.
  • Coenzyme Q10 can reduce the hazardous effects of ultraviolet A (UVA) radiations on the dermal fibroblast and maintain the dermal matrix. Hoppe U, Bergemann J, Diembeck W, Ennen J, Gohla S, Harris I, Jacob J, Kielholz J, Mei W, Pollet D, Schachtschabel D. Coenzyme Q_ {10}, a cutaneous antioxidant and energizer. Biofactors. 1999 Jan 1;9(2‐4):371-8.
  • Regular use of Q10 on skin can significantly protect the outermost skin layer in all the age categories. Knott A, Achterberg V, Smuda C, Mielke H, Sperling G, Dunckelmann K, Vogelsang A, Krüger A, Schwengler H, Behtash M, Kristof S. Topical treatment with coenzyme Q 10‐containing formulas improves skin's Q 10 level and provides antioxidative effects. Biofactors. 2015 Nov 12;41(6):383-90.
  Allantoin:  
  • Allantoin enables exfoliation of Skin. It has the property to exfoliate the skin removing the tough, dead layer of the skin and shed t off. As a result, allantoin keeps the skin soft and smooth. Savić VL, Nikolić VD, Arsić IA, Stanojević LP, Najman SJ, Stojanović S, Mladenović‐Ranisavljević II. Comparative study of the biological activity of allantoin and aqueous extract of the comfrey root. Phytotherapy Research. 2015 Aug;29(8):1117-22.
  • Allantoin plays an efficient role in synthesis of collagen which is responsible for skin to keep tight and wrinkle free. Pinsky MA. Efficacy and Safety of an Anti-aging Technology for the Treatment of Facial Wrinkles and Skin Moisturization. The Journal of clinical and aesthetic dermatology. 2017 Dec;10(12):27.
  • Allantoin & Wound Healing in multiple studies: Allantoin were tested for wound healing of the skin. Allantoin was found to sooth the injured skin and heal the wounds. No adverse effects to allantoin were reported (5 studies) Margraf HW, Covey TH. A trial of silver-zinc allantoinate in the treatment of leg ulcers. Arch Surg. 1977;112:699-704, Almeyda J, Wood H. Treatment of psoriasis: comparative study using allantoin coal tar extract combined with hydrocortisone and betamethasone valerate. Br J Clin Prac. 1979;33: 106-108, Willital GH, Heine H. Efficacy of Contracubex1 Gel in the treatment of fresh scars after thoracic surgery in children and adolescents. Int J Clin Pharm Res. 1994;14:193-202, Garnick JJ, Singh B, Winkley G. Effectiveness of a medicament containing silicon dioxide, aloe, and allantoin on aphthous stomatitis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998;86:550-556 and Wadhams PS, Griffith J, Nikravesh P, Chodosh D. Efficacy of a surfactant, allantoin, and benzalkonium chloride solution for onychomycosis. J Am Podiatr Med Assoc. 1999;89:124-130
  • Allantoin moisturizes the skin and protects it against irritation and dryness. It is even safe for sensitive skin types since no allergic or irritation reactions are induced by it. Sethi A, Kaur T, Malhotra SK, Gambhir ML. Moisturizers: the slippery road. Indian journal of dermatology. 2016 May;61(3):279.
  • Allantoin reduces the TEWL (transepidermal water-loss) which is responsible for making the skin loose and appear dry and itchy.
  • Oliveira G, Leverett JC, Emamzadeh M, Lane ME. The effects of heat on skin barrier function and in vivo dermal absorption. International journal of pharmaceutics. 2014 Apr 10;464(1-2):145-51.
  • Allantoin is Non-Irritating Kahan H, Schwartzman J, Sawicky HH. A new topical remedy for the prevention and management of napkin dermatitis (diaper rash). Arch Pediatr. 1956;73:12-29 and Kaessler HW. Dermatitis of the diaper area: a new remedy for an old affliction. Arch Pediatr. 1957;74:47-50.
    Palmitoyl Tripeptide-1 (Pal-GHK) (Skin Signaling Peptide):  
  • The activity of palmitoyl tripeptide-1 is comparable to retinoids, however, the peptide does not cause skin irritation. Errante, F., Ledwoń, P., Latajka, R., Rovero, P., & Papini, A. M. (2020). Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy. Front Chem, 8, 572923. https://doi.org/10.3389/fchem.2020.572923
  • Palmitoyl tripeptide-1 tends to promote collagen synthesis by the fibroblasts Lintner, K., & Peschard, O. (2000). Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. Int J Cosmet Sci, 22(3), 207-218. https://doi.org/10.1046/j.1467-2494.2000.00010.x
  • Palmitoyl tripeptide-1 modulates the catalytic activity of anti-proteases and metalloproteinases, thus, regulating the cutaneous protein breakdown. This prevents the accumulation of damaged proteins as well as prevents excessive proteolysis. Huang, P. J., Huang, Y. C., Su, M. F., Yang, T. Y., Huang, J. R., & Jiang, C. P. (2007). In vitro observations on the influence of copper peptide aids for the LED photoirradiation of fibroblast collagen synthesis. Photomed Laser Surg, 25(3), 183-190. https://doi.org/10.1089/pho.2007.2062
  • The skin regeneration is also improved via stimulation of epidermal basal cells and increased expression of integrins and p63 Kang, Y. A., Choi, H. R., Na, J. I., Huh, C. H., Kim, M. J., Youn, S. W., Kim, K. H., & Park, K. C. (2009). Copper-GHK increases integrin expression and p63 positivity by keratinocytes. Arch Dermatol Res, 301(4), 301-306. https://doi.org/10.1007/s00403-009-0942-x
  • Palmitoyl tripeptide-1 enhances wound healing by improving the contraction of the wound, synthesis of granular tissue, greater catalytic activity of antioxidant enzymes, and promoting the growth of blood vessels. (Arul et al., 2005; Canapp et al., 2003; Cangul et al., 2006; Gomes et al., 2017; Gul et al., 2008)
  • Palmitoyl Tripeptide-1 protect the skin keratinocytes against ultraviolet radiations of the sun. This also promotes the activity of antioxidant enzymes as well as inactivates the free radicals including glyoxal, 4-hydroxynoneal, malondialdehyde, and acrolein which are lipid peroxidation by-products. Beretta, G., Arlandini, E., Artali, R., Anton, J. M., & Maffei Facino, R. (2008). Acrolein sequestering ability of the endogenous tripeptide glycyl-histidyl-lysine (GHK): characterization of conjugation products by ESI-MSn and theoretical calculations. J Pharm Biomed Anal, 47(3), 596-602. https://doi.org/10.1016/j.jpba.2008.02.012
  • Palmitoyl Tripeptide-1 prevents low-density lipoprotein oxidation, suppressing the synthesis of free radicals. The peptide binds to lipid peroxidation products and prevents these from exerting damaging effects. Cebrián, J., Messeguer, A., Facino, R. M., & García Antón, J. M. (2005). New anti-RNS and -RCS products for cosmetic treatment. Int J Cosmet Sci, 27(5), 271-278. https://doi.org/10.1111/j.1467-2494.2005.00279.x and (Beretta et al., 2008; Beretta et al., 2007;)
    Palmitoyl Tripeptide-7 (Pal-GQPR) (Skin Signaling Peptide):  
  • Palmitoyl Tetrapeptide-7 reduces the release of IL-6. This helps modulate inflammation and prevents associated damage to the skin tissues. Also, Palmitoyl tetrapeptide-7 stimulates the production of collagen VII and laminin IV and V. Resende, D., Ferreira, M. S., Sousa-Lobo, J. M., Sousa, E., & Almeida, I. F. (2021). Usage of Synthetic Peptides in Cosmetics for Sensitive Skin. Pharmaceuticals (Basel), 14(8). https://doi.org/10.3390/ph14080702
  • Palmitoyl Tetrapeptide-7 is attributed to the restoration of normal levels of fibrillin-1 which is an important constituent of fibrillin-rich microfibrils. This significantly improves the skin texture. Watson, R. E., Ogden, S., Cotterell, L. F., Bowden, J. J., Bastrilles, J. Y., Long, S. P., & Griffiths, C. E. (2009). Effects of a cosmetic 'anti-aging' product improve photoaged skin [corrected]. Br J Dermatol, 161(2), 419-426. https://doi.org/10.1111/j.1365-2133.2009.09216.x
  • Palmitoyl tetrapeptide-7 suppresses the secretion of IL-6 which functions to reduce inflammation following exposure to ultraviolet B radiation. Resende, D., Ferreira, M. S., Sousa-Lobo, J. M., Sousa, E., & Almeida, I. F. (2021). Usage of Synthetic Peptides in Cosmetics for Sensitive Skin. Pharmaceuticals (Basel), 14(8). https://doi.org/10.3390/ph14080702
    Palmitoyl Tripeptide-5 (Pal-KVK) (Skin Signaling Peptide):  
  • Palmitoyl Tripeptide-5 is particularly for those who have sensitive skin types. Resende, D., Ferreira, M. S., Sousa-Lobo, J. M., Sousa, E., & Almeida, I. F. (2021). Usage of Synthetic Peptides in Cosmetics for Sensitive Skin. Pharmaceuticals (Basel), 14(8). https://doi.org/10.3390/ph14080702
  • Palmitoyl Tripeptide-5 stimulates the function of transforming growth factor-beta (TGF-β) which is responsible for collagen production and suppression of the activity of matrix metalloproteases that degrade collagen Errante, F., Ledwoń, P., Latajka, R., Rovero, P., & Papini, A. M. (2020). Cosmeceutical Peptides in the Framework of Sustainable Wellness Economy. Front Chem, 8, 572923. https://doi.org/10.3389/fchem.2020.572923 , and Trookman et al., 2009)
  • Palmitoyl Tripeptide-5 stimulates the production of type I and type III collagen by the fibroblasts in the dermis and plays a significant role in optimal wound healing contributes to the increased collagen concentration in the dermal extracellular matrix. Schagen, S. K. (2017). Topical peptide treatments with effective anti-aging results. Cosmetics, 4(2), 16.
  • Anti-inflammatory properties of palmitoyl tripeptide-5 are beneficial for inflammatory skin conditions and changes in the skin associated with dermal aging . Resende, D., Ferreira, M. S., Sousa-Lobo, J. M., Sousa, E., & Almeida, I. F. (2021). Usage of Synthetic Peptides in Cosmetics for Sensitive Skin. Pharmaceuticals (Basel), 14(8). https://doi.org/10.3390/ph14080702
  • Palmitoyl Tripeptide 5 an effective ingredient for inflamed and sensitive skin. . Resende, D., Ferreira, M. S., Sousa-Lobo, J. M., Sousa, E., & Almeida, I. F. (2021). Usage of Synthetic Peptides in Cosmetics for Sensitive Skin. Pharmaceuticals (Basel), 14(8). https://doi.org/10.3390/ph14080702
    Vitamin B3 (Niacinamide):
  • Niacinamide improved barrier functions & anti-aging benefits (. J Clin Dermatol. 2003;32S:9–18)
  • Niacinamide increases the biosynthesis of ceramides & stratum corneum lipids, improves epidermal permeability barrier. (Tanno O, Ota Y, Kitamura N, Katsube T, Inoue S Br J Dermatol. 2000 Sep; 143(3):524-31)
  • Niacinamide substantiates       the ability of Niacinamide to up-regulate dermal matrix collagen and protein production. (60th Annual Meeting of the American Academy of Dermatology. 2002; New Orleans & Intl Fed Soc Cosmet Chem Mag. 2002;5:285–289)
  • Niacinamide reduces levels of toxic radicals present inside the skin cells (Olsen A, Siboska GE, Clark BF, Rattan SI Biochem Biophys Res Commun. 1999 Nov 19; 265(2):499-502.)
  • Niacinamide potential effect of modulating the gene expression involved in cellular proliferation (Sefton J, Kligman AM, Kopper SC, Lue JC, Gibson JR J Am Acad Dermatol. 2000 Oct; 43(4):656-63)
  • Niacinamide reduces yellowing, wrinkling, red blotchiness, and hyper pigmentation (Bissett DL, Miyamoto K, Sun P, Li J, Berge CA Int J Cosmet Sci. 2004 Oct; 26(5):231-8)
  • Niacinamide improves aging facial skin appearance (Bissett DL, Oblong JE, Berge CA Dermatol Surg. 2005 Jul; 31(7 Pt 2):860-5; discussion 865)
  Glycerin/Glycerol:  
  • Glycerin/Glycerol protection against irritating stimuli, enhancement of desmosomal degradation, and acceleration of wound-healing processes. (Fluhr JW, Darlenski R, Surber C. Glycerol and the skin: holistic approach to its origin and functions.. PMID: 18510666.)
  • Glycerin/Glycerol Improvement of stratum corneum hydration, skin barrier function and skin mechanical properties, inhibition of the stratum corneum lipid phase transition. (Fluhr JW, Darlenski R, Surber C. Glycerol and the skin: holistic approach to its origin and functions.. PMID: 18510666.)
  • Glycerin/Glycerol increase the water content of epidermal and dermal. Likely to structural changes in the skin relief. (Caberlotto E, Cornillon C, Njikeu S, Monot M, Vicic M, Flament F. Synchronized in vivo measurements of skin hydration and trans-epidermal water loss. Exploring their mutual influences. Int J Cosmet Sci. 2019 Oct;41(5):437-442. doi: 10.1111/ics.12556. Epub 2019 Sep 4. PMID: 31310331.)
  • Glycerin/Glycerol - Skin hydration in the Stratum corneum (Verdier-Sévrain S, Bonté F. Skin hydration: a review on its molecular mechanisms. PMID: 17524122.)
    Pro-Vitamin B5 (Dexpanthenol):  
  • Dexpanthenol stabilizes the epidermal barrier by up-regulating the synthesis of proteins and sphingolipids (24- Camargo, F. B., Jr, Gaspar, L. R., & Maia Campos, P. M. (2011).)
  • Dexpanthenol causes both the proliferation and differentiation of fibroblasts, which then speeds up the wound healing process. It also accelerates the re-epithelization in wound healing by upregulating and stimulating keratinocyte proliferation (24- Camargo, F. B., Jr, Gaspar, L. R., & Maia Campos, P. M. (2011)
  • Dexpanthenol plays a vital role in subcellular signaling pathways and reduces inflammation around the skin. (22-Proksch, E., & Nissen, H. P. (2002))
  • Dexpanthenol reduced trans-epidermal water loss, improves the hydration of the stratum corneum and improves and stabilizes the epidermal barrier functioning of the skin. ( 23- Gehring, W., & Gloor, M. (2000))
  • Dexpanthenol enhances the moisturizing through collagen and keratinocyte growth (21- Kobayashi, D., Kusama, M., Onda, M., & Nakahata, N. (2011).)
 
Shopping Cart