Peptides for skin – How they help psoriasis, eczema and anti-aging

As someone who has long been suffering from skin psoriasis or eczema, you must be of the belief that these conditions can’t be gotten rid of. Well, with peptides in a comprehensive psoriasis cream, it is not as difficult as you think, and we have proven reasons to say that.

With the advancement in the cosmeceutical and biopharmaceutical industry, Peptides have become the new cliché in skincare. They have long been discussed for their anti-aging properties and the debate is focused on one simple question, “Are they worth investing your hard-earned dollars in?

“Yes” is simply the answer.

Before discussing the science behind, it is important to understand what amino acids and peptides actually are.

Peptides are a main building block of life

Amino acids are micro molecules that combine to form peptides chains and extra-long peptide chains form proteins including collagen in the skin. Collagen is one of the many proteins that make up our cells. Proteins are complex macromolecules consisting of single or multiple long chains of amino acid monomers of more than 50 unit.  If the chain of amino acid units are between 2- 50 then t are called peptides. The peptides serve as fundamental building blocks for collagen and elastin fibers in the skin. These fibers are crucial for skin’s firmness and elasticity. 

Proteins, peptides, and amino acids are the building block lifelines for our body and skin. Every tangible thing in your body from your hair & nails to your skin, from your muscles to your bones is composed of proteins with collagen being the main skin protein. Seems interesting. Have these proteins damaged, you will notice wrinkled & distressed skin, brittle nails, and rough hair to name a few. Peptides are the basis of healthy proteins. The amino acid monomers and the resulting proteins constitute the second largest component of tissue & mussel with water being the largest. In the skin, water is the largest component followed by fats & lipids with collagen proteins being a close third.

Not only crucial for the skin’s structure and function, but these little siblings of proteins also act as miraculous energy sources for the body. The chemical messengers in the body, enzymes, and hormones are also peptides by nature. We need peptides at all times. If we are deficient in them, our body cannot function,” says Dr. Deanne Mraz Robinson, MD, FAAD.

Peptides such as Palmitoyl Tripeptide-5, a LipidTAC ingredient is a signaling peptide that sends out various signals or instructions. Here is what we know about Palmitoyl Tripeptide-5:

  1. It reduces the secretion of pro-inflammatory cytokines. This means it helps to keep the skin from getting inflamed which also reduces redness.
  2. It reduces the expression of metalloproteases. Metalloproteases is an enzyme that breaks down protein such as collagen. Metalloproteases causes the onset of aging and other signs of skin stresses. Reducing the expression of metalloproteases means to slow down the destruction of collagen and proteins.
  3. It improves the production of type I and type II collagen.

Peptides such as Palmitoyl Tetrapeptide-7, a LipidTAC ingredient is a signaling peptide that also sends out various signals or instructions. Here is what we know about Tetrapeptide-7:

  1. It reduces the secretion of IL-6 which improves inflammation associated with exposure to UV-B radiation.
  2. It improves production of laminin IV and laminin V. Laminins. Laminins regulate multiple cellular activities and signaling pathways.
  3. It improves the production of collagen VII.

Peptides such as Palmitoyl Tripeptide-1, a LipidTAC ingredient is both a signaling and carrier peptide that acts as a micro-nutrient carrier and it sends out various signals or instructions. Here is what we know about Palmitoyl Tripeptide-1:

  1. It is responsible for delivering copper.
  2. It signals for the degradation of collagen aggregates in scar tissue.
  3. It helps to regulate collagen synthesis. Synthesis means to make a more complex component from smaller less complex components. 
  4. It mediates antioxidant and anti-inflammatory responses.

Peptides in your skincare

The question that arises here is “if our body already has peptides, why do we need to apply more of them?”

Actually, as you enter your 30s, your body loses 1% of its remaining collagen with every passing year. The natural communication channels of the skin also slow down with age. This leads to wrinkled and damaged skin caused mainly by the reduction of healthy collagen proteins. This is where peptides make their entry. Here is an overview of how these little siblings of proteins work in your skin.

These peptides are actually cautioning signals that warn your body that it needs to heal. When the skin starts aging prematurely, the peptide signaling mechanism gets activated and requests the skin to produce more collagen and hyaluronic acid, revitalizing your skin and restoring a healthy skin barrier.

Introducing peptides to your skin in the form of creams, lotions, or serums, dodges the skin to think that there is an injury or wound, which in turn stimulates the collagen production mechanism thus off setting natural aging and also, improving the quality of skin In skin disorders.

The role of peptides in psoriasis, eczema and skin aging

Collagen peptides are derived from different types of collagen and have different anti-aging effects. Collagen peptide derived from type I collagen promotes the production of dermal matrix, elastin, fibrin, and procollagen I. 

These peptides promote the production of antioxidants such as glutathione and superoxide dismutase and reduce reactive oxygen species. They also prevent photo-aging of the skin and reduce the expression of collagenase and gelatinase.

Together, Collagen biosynthesis and wound healing, photo-aging repair effects, cellulite reduction, and reduced irritation properties make peptides effective ingredients in cosmetics for inflamed and sensitive skin as well as skin disorders. This helps in minimizing the symptoms of eczema, psoriasis, and dermatitis. 

 LipidTAC is here to help you with its peptide-rich creams, and lotions. LipidTAC uses three peptides in its LipidTAC 108 cream. These peptides are Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-5 and Palmitoyl Tripeptide-1.

 Due to their potency, peptides are not to be use alone and must be an extremely small percentage in topical formulations. Their conjugation with fatty acids improves their permeability and stability on the skin. Mitigating properties of palmitoyl tripeptide-5 are useful for inflammatory skin conditions and changes in the skin related to aging skin. Essentially, Palmitoyl tetrapeptide-7 stifles the secretion of IL-6 which reduces aggravation following radiation exposure. Palmitoyl tripeptide-1 will in general advance collagen amalgamation by the fibroblasts. All of these effects combine to be a strong equation against psoriasis, eczema, and anti-aging.

Take away….

 A comprehensive formulation that includes multiple types of peptides is what your skin was longing for. Now is the time to get rid of your dermatological problems once and for all. When trying to find a product with peptides, look for anything that ends with “peptide” or begins with “palmitoyl” on the ingredient label. Also, look for creams and lotions with a base of plant oils and/or plant seed oils. LipidTAC is that Plant oil base cream your skin will thrive on. LipidTAC is Exceptional Science with Extraordinary Results. It will flood your immune system with all the building blocks it needs along with the signaling instructions it’s missing. No doubt, this will help you age gracefully and conquer psoriasis, eczema and dermatitis and improve your aged skin dramatically.

References:

Ganceviciene, R., Liakou, A. I., Theodoridis, A., Makrantonaki, E., & Zouboulis, C. C. (2012). Skin anti-aging strategies. Dermatoendocrinol, 4(3), 308-319. https://doi.org/10.4161/derm.22804 

Gilbert, S. F., & Barresi, M. (2000). Developmental biology, ed. Sunderland (MA): Sinauer

Gorouhi, F., & Maibach, H. I. (2009). Role of topical peptides in preventing or treating aged skin. International Journal of Cosmetic Science, 31(5), 327-345. https://doi.org/https://doi.org/10.1111/j.1468-2494.2009.00490.x 

Hahn, H. J., Jung, H. J., Schrammek-Drusios, M. C., Lee, S. N., Kim, J. H., Kwon, S. B., An, I. S., An, S., & Ahn, K. J. (2016). Instrumental evaluation of anti-aging effects of cosmetic formulations containing palmitoyl peptides, Silybum marianum seed oil, vitamin E and other functional ingredients on aged human skin. Exp Ther Med, 12(2), 1171-1176. https://doi.org/10.3892/etm.2016.3447 

Lintner, K., & Peschard, O. (2000). Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. Int J Cosmet Sci, 22(3), 207-218. https://doi.org/10.1046/j.1467-2494.2000.00010.x

Resende, D., Ferreira, M. S., Sousa-Lobo, J. M., Sousa, E., & Almeida, I. F. (2021). Usage of Synthetic Peptides in Cosmetics for Sensitive Skin. Pharmaceuticals (Basel), 14(8). https://doi.org/10.3390/ph14080702 

Trookman, N. S., Rizer, R. L., Ford, R., Ho, E., & Gotz, V. (2009). Immediate and Long-term Clinical Benefits of a Topical Treatment for Facial Lines and Wrinkles. J Clin Aesthet Dermatol, 2(3), 38-43. 

Zhang, S., & Duan, E. (2018). Fighting against Skin Aging: The Way from Bench to Bedside. Cell Transplant, 27(5), 729-738. https://doi.org/10.1177/0963689717725755 

Zhao, X., Zhang, X., & Liu, D. (2021). Collagen peptides and the related synthetic peptides: A review on improving skin health. Journal of Functional Foods, 86, 104680. https://doi.org/https://doi.org/10.1016/j.jff.2021.104680

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